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Overexpression of cyclin D1 and cortactin is primarily independent of gene amplification in salivary gland adenoid cystic carcinoma

✍ Scribed by Robert O. Greer Jr.; Sherif Said; Kenneth R. Shroyer; Varella-Garcia Marileila; Scott A. Weed


Book ID
113832812
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
578 KB
Volume
43
Category
Article
ISSN
1368-8375

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p21WAF1/Cip1 is associated with cyclin D
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p21 WAF1/Cip1 is an inhibitor of cdk/cyclin complexes, and thus regulates the cell cycle. p21 is also related to cell differentiation and is regulated by wild-type p53, although p53-independent regulatory pathways have been proposed. In order to analyse p21 expression as well as its relationship wit