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Over-expression of renal LAT1 and LAT2 and enhanced L-DOPA uptake in SHR immortalized renal proximal tubular cells

✍ Scribed by Pinho, Maria Joao; Serrao, Maria Paula; Gomes, Pedro; Hopfer, Ulrich; Jose, Pedro A.; Soares-da-Silva, P.


Book ID
109066476
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
243 KB
Volume
66
Category
Article
ISSN
0085-2538

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Cl(-) /HCO (3)(-) exchanger and Na(+) /H(+) exchanger 3 are the main transporters responsible for NaCl reabsorption in kidney proximal tubules (PT). It is well accepted that membrane exchangers can be regulated by reactive oxygen species (ROS). In the kidney, ROS are known to contribute to decreases