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Outcome in acute lymphoblastic leukemia: Influence of thiopurine methyltransferase genetic polymorphisms

✍ Scribed by E. Oliveira; S. Alves; S. Quental; F. Ferreira; L. Norton; V. Costa; A. Amorim; M.J. Prata


Book ID
116538706
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
85 KB
Volume
1288
Category
Article
ISSN
0531-5131

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Frequency of thiopurine S-methyltransfer
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Background. Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation (inactivation) of mercaptopurine, azathioprine, and thioguanine, and exhibits genetic variation. About 11% of Caucasians have intermediate TPMT activity because of heterozygosity, and about 1 in 300 inherits TPMT deficienc