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Frequency of thiopurineS-methyltransferase mutant alleles in indigenous and admixed Guatemalan patients with acute lymphoblastic leukemia

✍ Scribed by Claudia Garrido, Veronica Giron Santizo, Petra Müllers…

Book ID
120899622
Publisher
Springer US
Year
2013
Tongue
English
Weight
215 KB
Volume
30
Category
Article
ISSN
1357-0560

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## Abstract 6‐Mercaptopurine (6MP) is an essential anticancer drug used in the treatment of childhood acute lymphoblastic leukemia (ALL). Thiopurine methyltransferase (TPMT) polymorphisms are the major determinants of interindividual differences in the severe toxicity or efficacy of 6MP. Four varia