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Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia

✍ Scribed by Krynetski, E Y; Relling, M V; Evans, W E; McLeod, H L


Book ID
110054503
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
155 KB
Volume
14
Category
Article
ISSN
0887-6924

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## Abstract Nowadays about two‐thirds of children with acute lymphoblastic leukemia (ALL) can be cured with chemotherapy, but one‐third die from the disease. The clinical response of leukemic cells to chemotherapy is roughly due to two factors: the effective drug levels reaching the cells and the r