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Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma

✍ Scribed by Hiroyuki Imanishi; Noboru Okamura; Mariko Yagi; Yukari Noro; Yuka Moriya; Tsutomu Nakamura; Akira Hayakawa; Yasuhiro Takeshima; Toshiyuki Sakaeda; Masafumi Matsuo; Katsuhiko Okumura


Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
182 KB
Volume
52
Category
Article
ISSN
1435-232X

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✍ Maja Krajinovic; Hugues Sinnett; Chantal Richer; Damian Labuda; Daniel Sinnett πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 French βš– 124 KB

## Abstract Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. The genetic factors underlying the susceptibility to this disease remain elusive. The enzymes CYP2E1, MPO and NQO1 are involved in the biotransformation of a variety of xenobiotics present in organic solvents, tobac