Genetic polymorphisms of folate metabolic enzymes and toxicities of high dose methotrexate in children with acute lymphoblastic leukemia
β Scribed by Samart Pakakasama; Kittima Kanchanakamhaeng; Saowanee Kajanachumpol; Umaporn Udomsubpayakul; Nongnuch Sirachainan; Amnuay Thithapandha; Suradej Hongeng
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 76 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0939-5555
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π SIMILAR VOLUMES
High-dose methotrexate (HDMTX, 1,000 mg/m2) and cranial irradiation/sequential chemotherapy (RTSC) were compared for ability to extend complete remission durations in children with acute lymphoblastic leukemia (ALL). Three hundred thirty patients were enrolled in the study, according to our criteria
## Abstract ## Background Tromboembolic and hemorrhagic complications are significant causes of death in patients with malignancy. These are wellβknown with the use of certain drugs. This study was planned to investigate whether there was any effect of highβdose methotrexate on the hemostatic syst