✦ LIBER ✦

Genetic determinants of methotrexate toxicity in rheumatoid arthritis patients: a study of polymorphisms affecting methotrexate transport and folate metabolism

✍ Scribed by Petra Bohanec Grabar; Dušan Logar; Boris Lestan; Vita Dolžan

Publisher: Springer
Year: 2008
Tongue: English
Weight: 269 KB
Volume: 64
Category: Article
ISSN: 0031-6970
DOI: 10.1007/s00228-008-0521-7

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Genetic polymorphisms of folate metaboli

Genetic polymorphisms of folate metabolic enzymes and toxicities of high dose methotrexate in children with acute lymphoblastic leukemia

✍ Samart Pakakasama; Kittima Kanchanakamhaeng; Saowanee Kajanachumpol; Umaporn Udo 📂 Article 📅 2007 🏛 Springer 🌐 English ⚖ 76 KB

Methotrexate metabolism analysis in bloo

Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients: Association with hepatic folate deficiency and formation of polyglutamates

✍ Joel M. Kremer; John Galivan; Anita Streckfuss; Barton Kamen 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 347 KB 👁 2 views

Efficacy and toxicity of methotrexate in

Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes

✍ Judith A. M. Wessels; Jeska K. de Vries-Bouwstra; Bas T. Heijmans; P. Eline Slag 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 97 KB 👁 2 views

Association of genetic polymorphism in t

Association of genetic polymorphism in the folate metabolic pathway with methotrexate pharmacokinetics and toxicity in childhood acute lymphoblastic leukaemia and malignant lymphoma

✍ Barbara Faganel Kotnik; Iztok Grabnar; Petra Bohanec Grabar; Vita Dolžan; Janez 📂 Article 📅 2011 🏛 Springer 🌐 English ⚖ 264 KB

Selective expression of folate receptor

Selective expression of folate receptor β and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis

✍ Noriko Nakashima-Matsushita; Toshio Homma; Su Yu; Takemasa Matsuda; Nobuhiko Sun 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 249 KB 👁 1 views

## Objective. To investigate the expression of folate receptors (FR) and reduced folate carrier (RFC) and determine their relevance to methotrexate (MTX) transport in synovial mononuclear cells (SMC) from patients with rheumatoid arthritis (RA). Methods. Levels of FR and RFC messenger RNA (mRNA) w

Testing pharmacogenetic indices to predi

Testing pharmacogenetic indices to predict efficacy and toxicity of methotrexate monotherapy in a rheumatoid arthritis patient cohort

✍ S. A. Owen; M. Lunt; S. L. Hider; I. N. Bruce; A. Barton; W. Thomson 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 76 KB 👁 2 views

SUDAAN 10 (Research Triangle Institute) and SAS 9.2 (SAS Institute) were used for the statistical analyses of data. The results from the NIS show that there were 788 cases of PCP among hospitalized patients with RA in the US from 1996 to 2007. Patients were mostly older (73.5% were ages 50-80 years