Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients: Association with hepatic folate deficiency and formation of polyglutamates

Polyglutamation of methotrexate with com

Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis

✍ Thierry Dervieux; Daniel Furst; Diana Orentas Lein; Robert Capps; Katie Smith; M 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 197 KB 👁 1 views

## Abstract ## Objective Methotrexate (MTX) enters cells through the reduced folate carrier (RFC‐1) and exerts part of its effects through polyglutamation to MTX polyglutamates (MTXPGs) and inhibition of 5‐aminoimidazole‐4‐carboxamide ribonucleotide transformylase (ATIC) and thymidylate synthase (