## Abstract Osteonecrosis of the jaws (ONJ) associated with the use of bisphosphonates is a newly described entity. To elucidate the mechanism leading to ONJ and to test the hypothesis that in patients with ONJ the bisphosphonates may interfere with endothelial cell proliferation, using flow cytome
Osteonecrosis of the jaw associated with pamidronate therapy
β Scribed by Ryan Zarychanski; Erin Elphee; Paul Walton; James Johnston
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 162 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0361-8609
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## Abstract ## Background Intravenous bisphosphonate therapy has been used for treatment of benign and malignant bone diseases and has been linked to osteonecrosis of the jaws. ## Methods Records of 638 patients treated with intravenous bisphosphonates were reviewed. Drug used, number of infusio
## Abstract ## Background. An increasing number of cases of osteonecrosis of the jaws (ONJ) in patients treated with bisphosphonates has been reported in the literature. ONJ significantly affects the patients' quality of life and its management is still extremely difficult. ## Methods. A woman w
## Abstract ## Background. Osteonecrosis of the jaws occurs after the administration of bisphosphonates. An unequivocal treatment strategy is yet to be devised. We assess the treatment of patients with bisphosphonateβrelated osteonecrosis of the jaws (BRONJ). ## Methods. The investigators studie
## Abstract Two unusual cases of osteonecrosis of the jaws in edentulous patients are described. One case involved the maxilla and the other the mandible. Both patients were compromised hosts who were undergoing cancer chemotherapy. Both developed local mucosal infections beneath their dentures bef