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Ortho metalation directed by .alpha.-amino alkoxides

✍ Scribed by Comins, Daniel L.; Brown, Jack D.


Book ID
126491321
Publisher
American Chemical Society
Year
1984
Tongue
English
Weight
740 KB
Volume
49
Category
Article
ISSN
0022-3263

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Ortho metalation directed by Ξ±-amino alk
✍ Daniel L. Comins; Jack D. Brown πŸ“‚ Article πŸ“… 1983 πŸ› Elsevier Science 🌐 French βš– 215 KB

Ortho-substituted aryl ketones are prepared from N-[2-(dimethylamino)ethy]-Nmethylbenzamides via ortho lithiation of intermediate a-amino alkoxides, formed in situ by addition of RLi. also described. An ortho lithiation of N-[2-(dimethylamino)ethyl]-N-methylbenzamide is Tertiary a-amino alkoxides, f

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## Abstract The __endo__‐ and __exo__‐rim positions of deep‐cavity cavitand **1** were functionalized by directed __ortho__ metalation (D__o__M) procedures. A range of electrophilic quenchers led to hosts with ester, phenol and thioether functionality. In each case, a combination of host pre‐organi

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## Abstract A new method for the preparation of benzoxazole‐[phenyl‐^13^C~6~] (**1**) starting from aniline‐[^13^C~6~] (**4**) has been developed involving directed __ortho__‐metalation (D__o__M) chemistry. The synthesis comprises four steps and an overall yield of 39% was obtained. Copyright Β© 200