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ortho-Carboranyl Glycosides for the Treatment of Cancer by Boron Neutron Capture Therapy

โœ Scribed by Lutz F Tietze; Ulrich Bothe; Ulrich Griesbach; Munekazu Nakaichi; Toshinari Hasegawa; Hiroyuki Nakamura; Yoshinori Yamamoto

Book ID
108479067
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
240 KB
Volume
9
Category
Article
ISSN
0968-0896

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Ortho-Carboranyl Glycosides of Glucose,
Ortho-Carboranyl Glycosides of Glucose, Mannose, Maltose and Lactose for Cancer Treatment by Boron Neutron-Capture Therapy
โœ Lutz F. Tietze; Ulrich Bothe ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 118 KB ๐Ÿ‘ 2 views

Glycosidation of alkynols using the trichloroacetimidate method led to the alkynyl glycosides 2 a,b, 6, 10 and 14 in 53 ยฑ 68 % yield, which by reaction with decaborane( ) afforded the protected peracetylated o-carboranyl glycosides 3 a,b, 7, 11 and 15 in 43 ยฑ 61 % yield. Base-catalyzed solvolysis ga