Ornithine as a precursor for the pyrrolidine ring of nicotine
β Scribed by Burton L. Lamberts; Lovell J. Dewey; Richard U. Byerrum
- Book ID
- 115788478
- Publisher
- Elsevier Science
- Year
- 1959
- Weight
- 318 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0006-3002
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π SIMILAR VOLUMES
When ornithine-2-C" was fed to intact tobacco plants radioactive nicotine (VII) was obtained in which essentially all the activity was located at C2 and C5 of the pyrrolidine ring and was equally divided between these positions (1,2). A similar result was obtained when glutamic acid-2-C l4 (3,4) or
## Abstract Ornithine aminotransferase catalyzes the reversible transamination of Lβornithine to Ξ΄^1^βpyrrolineβ5βcarboxylate, the immediate precursor of proline. The direction and flux through this pathway in mammalian cells has not been established. Glutamate has generally been considered to be t