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Ornatins: potent glycoprotein IIb-IIIa antagonists and platelet aggregation inhibitors from the leech Placobdella ornata

โœ Scribed by Paul MAZUR; William J. HENZEL; Jana L. SEYMOUR; Robert A. LAZARUS


Book ID
115128958
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
208 KB
Volume
202
Category
Article
ISSN
1432-1327

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Structural optimization of amidinoindole and amidinobenzofuran carboxylic amides leads to a series of compounds, among which analogues (I)-(III) exhibit potent in vitro activity in platelet aggregation assays and function as very potent and specific GPIIb-IIIa antagonists. -(SU, T.