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Fibrinogen Receptor (GPIIb-IIIa) Antagonists Derived from 5,6-Bicyclic Templates. Amidinoindoles, Amidinoindazoles, and Amidinobenzofurans Containing the N -α-Sulfonamide Carboxylic Acid Function as Potent Platelet Aggregation Inhibitors

✍ Scribed by Su, Ting; Naughton, Mary Ann H.; Smyth, Mark S.; Rose, Jack W.; Arfsten, Ann E.; McCowan, Jefferson R.; Jakubowski, Joseph A.; Wyss, Virginia L.; Ruterbories, Kenneth J.; Sall, Daniel J.; Scarborough, Robert M.

Book ID: 120394626
Publisher: American Chemical Society
Year: 1997
Tongue: English
Weight: 558 KB
Volume: 40
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm9704863

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ChemInform Abstract: Fibrinogen Receptor

ChemInform Abstract: Fibrinogen Receptor (GPIIb-IIIa) Antagonists Derived from 5,6-Bicyclic Templates. Amidinoindoles, Amidinoindazoles, and Amidinobenzofurans Containing the N-α-Sulfonamide Carboxylic Acid Function as Potent Platelet Aggregation Inhibitors.

✍ T. SU; et al. et al. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views

Structural optimization of amidinoindole and amidinobenzofuran carboxylic amides leads to a series of compounds, among which analogues (I)-(III) exhibit potent in vitro activity in platelet aggregation assays and function as very potent and specific GPIIb-IIIa antagonists. -(SU, T.