✦ LIBER ✦
ChemInform Abstract: Fibrinogen Receptor (GPIIb-IIIa) Antagonists Derived from 5,6-Bicyclic Templates. Amidinoindoles, Amidinoindazoles, and Amidinobenzofurans Containing the N-α-Sulfonamide Carboxylic Acid Function as Potent Platelet Aggregation Inhibitors.
✍ Scribed by T. SU; et al. et al.
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 34 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Structural optimization of amidinoindole and amidinobenzofuran carboxylic amides leads to a series of compounds, among which analogues (I)-(III) exhibit potent in vitro activity in platelet aggregation assays and function as very potent and specific GPIIb-IIIa antagonists. -(SU, T.