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Original reaction of p-nitrobenzyl chloride with aldehydes using tetrakis(dimethylamino)ethylene (TDAE)

✍ Scribed by Gamal Giuglio-Tonolo; Thierry Terme; Maurice Médebielle; Patrice Vanelle


Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
91 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis


A series of disubstituted diarylethanols was prepared in moderate to good yields by reaction of p-nitrobenzyl chloride (1) with various aromatic aldehydes (2-12) in presence of tetrakis(dimethylamino)ethylene (TDAE).


📜 SIMILAR VOLUMES


Reaction of the 2-(bromodifluoromethyl)b
✍ Conrad Burkholder; William R. Dolbier Jr; Maurice Médebielle 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 216 KB

Tetrakis(dimethylamino)ethylcne (TDAE) was fimnd to be an effective reductant of the 2-(bromodifluoromethyl)benzoxazole 1. The generated 2-(difluoromethyl) benzoxazole anion was trapped with several aldehydes 2-9, under mild conditions, to give the corresponding 2-(difluoromcthyl)benzoxazole alcohol