𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Reaction of the 2-(bromodifluoromethyl)benzoxazole with tetrakis(dimethylamino)ethylene (TDAE) in the presence of aldehydes. A convenient synthesis of 2-(difluoromethyl)benzoxazole alcohols

✍ Scribed by Conrad Burkholder; William R. Dolbier Jr; Maurice Médebielle

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
216 KB
Volume
38
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Tetrakis(dimethylamino)ethylcne (TDAE) was fimnd to be an effective reductant of the 2-(bromodifluoromethyl)benzoxazole 1. The generated 2-(difluoromethyl) benzoxazole anion was trapped with several aldehydes 2-9, under mild conditions, to give the corresponding 2-(difluoromcthyl)benzoxazole alcohols 10-17, in moderate to good yields.

📜 SIMILAR VOLUMES

ChemInform Abstract: A Convenient Coupli
ChemInform Abstract: A Convenient Coupling Reaction of Isocyanates with t-Alcohols with Catalytic Amount of SmI2 in the Presence of HMPA.
✍ Y. H. KIM; H. S. PARK 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

1998 carbamic acid derivatives carbamic acid derivatives (acyclic compounds) P 0480 25 -089 A Convenient Coupling Reaction of Isocyanates with t-Alcohols with Catalytic Amount of SmI 2 in the Presence of HMPA. -Crowded alcohols such as (II) readily react with isocyanates under optimized conditions A