Organotin(IV) compounds of 2-thiopyridine. Crystal and molecular structure of dicyclohexyltin(IV) bis(2-pyridylthiolate)

✍ Scribed by Mohammed Bouâlam; Jacqueline Meunier-Piret; Monique Biesemans; Rudolph Willem; Marcel Gielen

• Book ID: 104138768
• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 549 KB
• Volume: 198-200
• Category: Article
• ISSN: 0020-1693
• DOI: 10.1016/s0020-1693(00)92367-3

✦ Synopsis

Dicyclohexyltin(IV) bis(2_pyridylthiolate), compound 1, crystallizes in the orthorhombic system, a = 16&N(3), b=40.315(8) and c =7.113(3). Its molecular structure is best described as a tetrahedron, based on the two carbon-tin and the two sulfur-tin bonds, which is however strongly distorted as a consequence of two weak additional nitrogen-tin bonds. Compound 1 and four other diorganotin(IV) bis(2-pyridylthiolates) are characterized by Mijssbauer, 'H, "C and '19Sn NMR spectroscopy, and by FAR mass spectrometry. Their in vitro antitumour activity against two human tumour cell lines: MCF-7 and WiDr is reported. The ID= values found are comparable to those found for crk-platin, but deceptively higher than for many other diorganotin compounds. N-SD-S 60.7(2) N-Sn-C(7) 79.5(3) C(2)-S-Sn 90.7(2) C(12)-C(7)-Sn 112.6(4) C(7)*-Sn-C(7) 126.9(3) 2-Pyridinethiolate ligand C(2)_S 1.769(6) C(2)-N 1.339(7) C(6)_N 1.339(9) C(2w3) 1.394(7) C(4)-c(3) 1.376(11) C(4tc(5) 1.382(11) C(6)-c(5) 1.374(9) Cyclohexyl group C(8)-c(7) 1.517(7) C(l2w7) 1.520(8) C(8)-c(9) 1.532(8) C(lO)-c(9) 1.495(12) C(lO)-C(ll) 1.525(12) C(l2)-cW) 1.517(10) San-S S--&-C(7) N-Sn-S* N-Sn-C(7)* C(8)-C(7)-Sn C(7)*-Sn-S