Reactive (ally1 and benzyl) Grignard reagents have been shorn to add to the double bond of allylic alcohols (I; Rv = H or Ar); the intermediates foraed in this reaction are probably the cyclic adducts II, vhich are themselves Grignard reagents and lead to a variety of products when treated vith suit
Organolithium additions to allylic alcohols
β Scribed by J.K. Crandall; A.C. Clark
- Publisher
- Elsevier Science
- Year
- 1969
- Tongue
- French
- Weight
- 181 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Simple organolithium reagents do not generally add to nonconjugated olefins'; although instances of such reactions have been reported in which particularly strained olefins were used,lj2 a substantially more stable organolithium species was formed,lJ4 or the reaction was intramolecular in nature'.
π SIMILAR VOLUMES
The reaction of aryl-and vinylpalladium compounds with vinylic and allylic epoxides provides an excellent, high yielding, regio-and stereoselective route to functionally substituted allylic alcohols which can be made catalytic in palladium. The reaction of vinylic epoxides and organolithium, -magnes
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