𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Organocatalyzed Cascade Reactions of Cyclic β-Enamino Esters and α,β-Unsaturated Aldehydes Leading to Indoloquinolizidines and Benzoquinolizidines

✍ Scribed by Xiaoyu Wu; Linlin Nie; Huihui Fang; Jie Chen; Weiguo Cao; Gang Zhao

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
545 KB
Volume
2011
Category
Article
ISSN
1434-193X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Organocatalyzed cascade reactions between cyclic β‐enamino esters and α,β‐unsaturated aldehydes have been developed. They provide highly substituted indolo[2,3‐a]quinolizidines and benzo[a]quinolizidines in moderate to good yields and with good to excellent enantioselectivities. Both aromatic and aliphatic α,β‐unsaturated aldehydes react readily with enamino esters to furnish the desired products.

📜 SIMILAR VOLUMES

Cascade Reactions: Sequential Homobimeta
Cascade Reactions: Sequential Homobimetallic Catalysis Leading to Benzofurans and β,γ-Unsaturated Esters
✍ Bartolo Gabriele; Raffaella Mancuso; Giuseppe Salerno; Mirco Costa 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 152 KB

## Abstract The concatenation between a Pd(0)‐promoted deallylation catalytic cycle and a Pd(II)‐promoted heterocyclization catalytic cycle (an example of what we have named “sequential homobimetallic catalysis”) has been shown to occur starting from 1‐(2‐allyloxyphenyl)‐2‐yn‐1‐ols **1** to afford

Enantioselective Organocatalytic Conjuga
Enantioselective Organocatalytic Conjugate Addition of Aldehydes to α,β-Unsaturated Thiol Esters
✍ Shaolin Zhu; You Wang; Dawei Ma 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 184 KB 👁 1 views

## Abstract The first example of an organocatalytic asymmetric Michael addition of aldehydes to α,β‐unsaturated thiol esters promoted by chiral diphenylprolinol silyl ether is presented. The reaction occurs with good yields, diastereoselectivity and excellent enantioselectivity.