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Organocatalyzed Asymmetric Synthesis of Dihydrodibenzofurans Based on a Dienamine Process

✍ Scribed by Wang, Zi-Yu; Wong, Wing-Tak; Yang, Dan


Book ID
121190075
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
547 KB
Volume
15
Category
Article
ISSN
1523-7060

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An asymmetric synthesis of isocarbacyclin (2) was achieved (97% ee), whose conversion to 8 has been already described, was isolated in 90% yield. The key step in the sequence from ketone 7 by the olefination-isomerization-coupling process with chiral sulfoximines. The vinylic sulfoximine 6 leading t