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Organocatalytic Asymmetric Michael-Type/Wittig Reaction of Phosphorus Ylides: Synthesis of Chiral α-Methylene-δ-Ketoesters

✍ Scribed by Lin, Aijun; Wang, Junying; Mao, Haibin; Ge, Huiming; Tan, Renxiang; Zhu, Chengjian; Cheng, Yixiang


Book ID
118069590
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
810 KB
Volume
13
Category
Article
ISSN
1523-7060

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Asymmetric organocatalytic Michael-type
✍ Suresh Allu; Sermadurai Selvakumar; Vinod K. Singh 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 288 KB

We report, for the first time, asymmetric organocatalytic Michael-type addition of stabilized phosphorus ylides to nitroolefins mediated by bisthiourea catalyst. Its subsequent reaction with formaldehyde provides c-nitro-a-methylene carboxylic esters in moderate to good yields and enantioselectiviti