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Organocatalytic Enantioselective Mannich-Type Reaction of Phosphorus Ylides: Synthesis of Chiral N-Boc-β-Amino-α-methylene Carboxylic Esters

✍ Scribed by Zhang, Yan; Liu, Yan-Kai; Kang, Tai-Ran; Hu, Ze-Kai; Chen, Ying-Chun

Book ID
111680001
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
50 KB
Volume
130
Category
Article
ISSN
0002-7863

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Asymmetric organocatalytic Michael-type
Asymmetric organocatalytic Michael-type reaction of phosphorus ylides to nitroolefins: synthesis of γ-nitro-β-aryl-α-methylene carboxylic esters
✍ Suresh Allu; Sermadurai Selvakumar; Vinod K. Singh 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 288 KB

We report, for the first time, asymmetric organocatalytic Michael-type addition of stabilized phosphorus ylides to nitroolefins mediated by bisthiourea catalyst. Its subsequent reaction with formaldehyde provides c-nitro-a-methylene carboxylic esters in moderate to good yields and enantioselectiviti