Organization of proximal signal initiation at the TCR:CD3 complex
β Scribed by Clifford S. Guy; Dario A. A. Vignali
- Book ID
- 111249057
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 136 KB
- Volume
- 232
- Category
- Article
- ISSN
- 0105-2896
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Dissection of the CD4 signal transduction pathway has revealed striking similarities with the TCR/CD3 pathway. Furthermore, downstream signaling by CD4 is impaired in cells lacking surface TCR, suggesting a role for the TCR/CD3 complex in CD4 signal transduction. We have investigated the molecular b
The TCR/CD3 complex is composed of six subunits which are expressed on the cell surface in a coordinate fashion after assembly in the endoplasmic reticulum (ER). The TCR/CD3 complex is assembled after a series of pairwise interactions involving the formation of dimers of CD3 epsilon with either CD3