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Assembly and stoichiometry of the TCR/CD3 complex

✍ Scribed by E. San José; B. Alarcón

Book ID
108409127
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
177 KB
Volume
56
Category
Article
ISSN
0165-2478

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Assembly of the TCR/CD3 complex: CD3ϵ/δ
Assembly of the TCR/CD3 complex: CD3ϵ/δ and CD3ϵ/γ dimers associate indistinctly with both TCRα and TCRβ chains. Evidence for a double TCR heterodimer model
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The TCR/CD3 complex is composed of six subunits which are expressed on the cell surface in a coordinate fashion after assembly in the endoplasmic reticulum (ER). The TCR/CD3 complex is assembled after a series of pairwise interactions involving the formation of dimers of CD3 epsilon with either CD3

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Dissection of the CD4 signal transduction pathway has revealed striking similarities with the TCR/CD3 pathway. Furthermore, downstream signaling by CD4 is impaired in cells lacking surface TCR, suggesting a role for the TCR/CD3 complex in CD4 signal transduction. We have investigated the molecular b