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Organization and maintenance of immunological memory by stroma niches

✍ Scribed by Koji Tokoyoda; Sandra Zehentmeier; Hyun-Dong Chang; Andreas Radbruch

Book ID
102165941
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
163 KB
Volume
39
Category
Article
ISSN
0014-2980

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Immunological memory is still one of the enigmas of modern immunology. We poorly understand the generation of memory cells from their precursors, the lifestyle of memory cells or their maintenance, reactivation and termination. Here, we discuss the recent evidence suggesting that memory plasma cells, as defined in this review, and memory Th cells are maintained in the bone marrow, resting (in terms of proliferation) in survival niches organized by dedicated stroma cells, which control the homeostasis of immunological memory.

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