Prolongation of skin graft survival in mice by in vitro PUVA treatment and failure of induction of specific immunological memory by PUVA-treated grafts

✍ Scribed by S. Gruner; H. Meffert; E. Karasek; N. Sönnichsen

• Publisher: Springer-Verlag
• Year: 1984
• Tongue: English
• Weight: 395 KB
• Volume: 276
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00511060

✦ Synopsis

Treatment of murine skin grafts in vitro with 8-methoxypsoralen and longwave ultraviolet radiation prolonged their subsequent survival on allogeneic recipients, but not in cases where the recipients had been presensitized by a former skin graft of the same donor strain. In contrast to normal skin, grafts pretreated with 8-methoxypsoralen and longwave ultraviolet radiation were not able to induce an immunological memory as revealed by a second transplantation of normal skin. The results show that primary and secondary skin graft rejection can be affected by the combined action of psoralen and ultraviolet radiation.