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Organization and chromosomal locations ofRap1a/Krevsequences in the mouse

✍ Scribed by Nancy A. Dower; Michael F. Seldin; Sherri Pugh; James C. Stone

Publisher: Springer-Verlag
Year: 1992
Tongue: English
Weight: 917 KB
Volume: 3
Category: Article
ISSN: 0938-8990
DOI: 10.1007/bf00352461

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✦ Synopsis

The human RAPIA gene encodes a protein that apparently can antagonize the function of oncogenic ras genes in gene transfer experiments, but its normal function is unknown. To understand the function of this gene, we have undertaken a study of the mouse homolog, Rapla. The complete coding sequence of a mouse Rapla cDNA has been determined, and genomic clones representing three distinct Rapla species were recovered. We find that Rapla is located on distal mouse Chromosome (Chr) 3 near Nras, Ampd-1, Tshb, Ngfb, and Atplal. Two related sequences (Rapla-rsl and Rapla-rs2) were also characterized. Rapla-rsl, which was not localized, has a sequence very similar to the Rapla cDNA, suggesting that it has been recently acquired by the mouse genome. Rapla-rs2 is more distantly related to the gene sequence and is located on Chr 2 near Actc-1.

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