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Chromosomal locations of genes encoding 2′,3′ cyclic nucleotide 3′-phosphodiesterase and glial fibrillary acidic protein in the mouse

✍ Scribed by L. Bernier; D. R. Colman; P. D'Eustachio

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
650 KB
Volume
20
Category
Article
ISSN
0360-4012

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✦ Synopsis

Cyclic nucleotide phosphodiesterase (CNP) and glial fibrillary acidic protein (GFAP) are useful markers of myelin and astroglia, respectively. Two proteins with CNP activity are known to exist in brain and lymphoid tissues. They appear to be the products of several distinct but related messenger ribonucleic acid (mRNA) species. GFAP is a single protein encoded by a single mRNA. We have localized the GFAP gene to distal chromosome 11 in the mouse. There are two genetic loci identified by CNP probes, one is closely linked to the GFAP gene, and the other maps to chromosome 3.

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