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Oreganic acid: a potent novel inhibitor of ras farnesyl-protein transferase from an endophytic fungus

✍ Scribed by Hiranthi Jayasuriya; Gerald F. Bills; Carmen Cascales; Deborah L. Zink; Michael A. Goetz; Rosalind G. Jenkins; Keith C. Silverman; Russell B. Lingham; Sheo B. Singh

Book ID: 108039051
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 253 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00372-1

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## Famesyl-Protein transfuase catalyses a post-translational mociificadon of Ras that is obligatory for the cell trarqtorming activity of this oncogene protebt. The screening of natural products to iden@fy inhibitors of this enzyme as a potential anticancer agents. has led to the isolation #two nove