Beta-amino acid derivatives as orally ac
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Georg Kottirsch; Hans-Günther Zerwes; Nigel S. Cook; Carlo Tapparelli
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Article
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1997
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Elsevier Science
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English
⚖ 306 KB
The ornithine sulfonamide 1 was identified by random screening as weak fibrinogen receptor antagonist. Homologation of the carboxylic acid function and further structure activity studies led to the development of novel beta-amino acid derivatives, which are potent and orally active antagonists of th