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Orally Active Fibrinogen Receptor Antagonists. 2. Amidoximes as Prodrugs of Amidines †

✍ Scribed by Weller, Thomas; Alig, Leo; Beresini, Maureen; Blackburn, Brent; Bunting, Stuart; Hadváry, Paul; Hürzeler Müller, Marianne; Knopp, Dietmar; Levet-Trafit, Bernard; Lipari, M. Terry; Modi, Nishit B.; Müller, Marcel; Refino, Canio J.; Schmitt, Monique; Schönholzer, Peter; Weiss, Sabine; Steiner, Beat


Book ID
120521189
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
266 KB
Volume
39
Category
Article
ISSN
0022-2623

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The ornithine sulfonamide 1 was identified by random screening as weak fibrinogen receptor antagonist. Homologation of the carboxylic acid function and further structure activity studies led to the development of novel beta-amino acid derivatives, which are potent and orally active antagonists of th