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Beta-amino acid derivatives as orally active non-peptide fibrinogen receptor antagonists

✍ Scribed by Georg Kottirsch; Hans-Günther Zerwes; Nigel S. Cook; Carlo Tapparelli

Book ID: 104364907
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 306 KB
Volume: 7
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(97)00095-4

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✦ Synopsis

The ornithine sulfonamide 1 was identified by random screening as weak fibrinogen receptor antagonist. Homologation of the carboxylic acid function and further structure activity studies led to the development of novel beta-amino acid derivatives, which are potent and orally active antagonists of the platelet fibrinogen receptor GPUb/IIIa.

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