๐”– Bobbio Scriptorium
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ChemInform Abstract: Non-Peptide Fibrinogen Receptor Antagonists. Part 7. Design and Synthesis of a Potent, Orally Active Fibrinogen Receptor Antagonist.

โœ Scribed by M. E. DUGGAN; A. M. NAYLOR-OLSEN; J. J. PERKINS; P. S. ANDERSON; C. T.-C. CHANG; J. J. COOK; R. J. GOULD; N. C. IHLE; G. D. HARTMAN; J. J. LYNCH; R. J. LYNCH; P. D. MANNO; L. W. SCHAFFER; R. L. SMITH


Book ID
112024145
Publisher
John Wiley and Sons
Year
2010
Weight
37 KB
Volume
26
Category
Article
ISSN
0931-7597

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Low molecular weight non-peptide inhibitors of platelet aggregation based on rigid bicyclic scaffolds are described. Consideration of the reported conformational preferences of 1-alkyl-3-carbonyl pyrroles led to the synthesis of pyrrolopiperazinone 2a which was shown to be a potent, selective antago