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Enantiospecific synthesis of SB 214857, a potent, orally active, nonpeptide fibrinogen receptor antagonist

โœ Scribed by William H. Miller; Thomas W. Ku; Fadia E. Ali; William E. Bondinell; Raul R. Calvo; Larry D. Davis; Karl F. Erhard; Leon B. Hall; William F. Huffman; Richard M. Keenan; Chet Kwon; Kenneth A. Newlander; Stephen T. Ross; James M. Samanen; Dennis T. Takata; Chuan-Kui Yuan

Book ID
103400833
Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
259 KB
Volume
36
Category
Article
ISSN
0040-4039

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โœ T.G. Hamill; M.E. Duggan; G.D. Hartman; W.F. Hoffman; J.J. Perkins; H.D. Burns ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 407 KB ๐Ÿ‘ 1 views

The synthesis of [3H]L-734,217, lb, an orally active fibrinogen receptor antagonist, is described. The conversion of 3-amino crotonate 6 to [3H]L-734,217 was carried out via a two step sequence of catalytic tritiation followed by basic hydrolysis. Deuterium model reactions showed that the reduction