A new synthesis of the GPIIb/IIIa receptor antagonist SB-214857-A
โ Scribed by Ian P Andrews; Richard J Atkins; Neil F Badham; Richard K Bellingham; Gary F Breen; John S Carey; Stephen K Etridge; Jerome F Hayes; Nigel Hussain; David O Morgan; Andrew C Share; Stephen A.C Smith; Timothy C Walsgrove; Andrew S Wells
- Book ID
- 104230908
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 74 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Platelet-membrane surface receptors are important targets for pharmacologic intervention in cardiovascular disease. Among these, glycoprotein (GP) IIb-IIIa is dominant and integrally involved in platelet aggregation and thrombus formation. When activated, GPIIb-IIIa binds soluble fibrinogen (Fb) in
The Enantiospecific Synthesis of an Isoxazoline. A RGD Mimic Platelet GPIIb/IIIa Antagonist. -The crystalline compound (VI), is synthesized on a multikilogram scale in 8 steps in 37% overall yield and ยฟ99.