ChemInform Abstract: The Enantiospecific Synthesis of an Isoxazoline. A RGD Mimic Platelet GPIIb/IIIa Antagonist.

✍ Scribed by L. ZHANG; J. C. CHUNG; T. D. COSTELLO; I. VALVIS; P. MA; S. KAUFFMAN; R. WARD

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 31 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199736147

✦ Synopsis

The Enantiospecific Synthesis of an Isoxazoline. A RGD Mimic Platelet GPIIb/IIIa Antagonist.

-The crystalline compound (VI), is synthesized on a multikilogram scale in 8 steps in 37% overall yield and ¿99.