𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Orally active chelators for the treatment of iron overload diseases

✍ Scribed by Alex P. Chin; Paul V. Bernhardt; Des R. Richardson


Book ID
108403854
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
110 KB
Volume
96
Category
Article
ISSN
0162-0134

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Selection of a new generation of orally
✍ G. J. Kontoghiorghes; J. Barr; P. Nortey; L. Sheppard πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 909 KB

The prospect of selecting oral a-ketohydroxypyrldine chelators Intended for clinical use in iron overload has been examined using several animal models of efficacy and toxicity. Studies using iron dextran-loaded mice labelled with 50Fe have shown that only the 1-substituted methyl, ethyl, (n)propyl,

Redox Properties of the Iron Complexes o
✍ Martin Merkofer; Reinhard Kissner; Robertβ€…C. Hider; Willemβ€…H. Koppenol πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 German βš– 645 KB

## Abstract Redox cycling of iron is a critical aspect of iron toxicity. Reduction of a low‐molecular‐weight iron(III)‐complex followed by oxidation of the iron(II)‐complex by hydrogen peroxide may yield the reactive hydroxyl radical (OH^.^) or an oxoiron(IV) species (the __Fenton__ reaction). Comp