Use of the oral chelator deferiprone in the treatment of iron overload in patients with Hb H disease
โ Scribed by Joyce C. W. Chan; Chor-Sang Chim; Clara G. C. Ooi; Bernard Cheung; Raymond Liang; Tai-Kwong Chan; Vivian Chan
- Book ID
- 108673658
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 225 KB
- Volume
- 133
- Category
- Article
- ISSN
- 0007-1048
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๐ SIMILAR VOLUMES
The prospect of selecting oral a-ketohydroxypyrldine chelators Intended for clinical use in iron overload has been examined using several animal models of efficacy and toxicity. Studies using iron dextran-loaded mice labelled with 50Fe have shown that only the 1-substituted methyl, ethyl, (n)propyl,
Gerbils administered iron dextran are the only animal species which have been shown to develop hemochromatosis of the liver and heart in the same manner as transfusion dependent homozygous thalassemics. The iron chelating hydroxypyridinone, CP94, has been administered prophylactically to iron overlo