Iron chelating agents for the treatment of iron overload
โ Scribed by Guido Crisponi; Maurizio Remelli
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 747 KB
- Volume
- 252
- Category
- Article
- ISSN
- 0010-8545
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The prospect of selecting oral a-ketohydroxypyrldine chelators Intended for clinical use in iron overload has been examined using several animal models of efficacy and toxicity. Studies using iron dextran-loaded mice labelled with 50Fe have shown that only the 1-substituted methyl, ethyl, (n)propyl,