Oral piritrexim — A phase II study in patients with advanced soft tissue sarcoma
✍ Scribed by Judith D. Schiesel; Matthew Carabasi; Gordon Magill; Ephraim Casper; Edgar Cheng; Linda Marks; Jan Feyzi; Neil J. Clendeninn; Richard V. Smalley
- Publisher
- Springer US
- Year
- 1992
- Tongue
- English
- Weight
- 129 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0167-6997
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## Abstract ## BACKGROUND The authors conducted a 2‐arm Phase II trial of 9‐nitrocamptothecin (9‐NC), an oral topoisomerase I inhibitor, to define response rates in patients with gastrointestinal (GI) leiomyosarcomas and other soft‐tissue sarcomas (STS). ## METHODS Patients were required to prov
Thirty-six previously treated adult patients with advanced soft tissue sarcomas received CPDD 120 mg/m2 with mannitol diuresis. There were only two (6%) partial responses and five (15%) minor responses in 34 evaluable patients. Toxicity included nausea and vomiting, myelosuppression, mild ototoxicit