✦ LIBER ✦

Phase II trial of cisplatin (CPDD) in previously treated patients with advanced soft tissue sarcoma

✍ Scribed by Joseph Brenner; Gordon B. Magill; Peter P. Sordillo; Edgar W. Cheng; Allan Yagoda

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 249 KB
Volume: 50
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19821115)50:10<2031::aid-cncr2820501010>3.0.co;2-z

No coin nor oath required. For personal study only.

✦ Synopsis

Thirty-six previously treated adult patients with advanced soft tissue sarcomas received CPDD 120 mg/m2 with mannitol diuresis. There were only two (6%) partial responses and five (15%) minor responses in 34 evaluable patients. Toxicity included nausea and vomiting, myelosuppression, mild ototoxicity and mild to moderate, transient nephrotoxicity. CPDD has minimal antitumor activity in previously treated patients with soft tissue sarcomas.

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