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Oral bioavailability and pharmacokinetics of DRF-4367, a new cox-2 inhibitor in rats

โœ Scribed by Mullangi Ramesh; Rao N. V. S. Mamidi; Kota Jagannath; Sunil Kumar Singh; Kalleda Srinivasa Rao; Yeleswarapu Koteswar Rao; Casturi Seshagirirao; Ramanujam Rajagopalan; Nuggehallyr Srinivas

Book ID
105731718
Publisher
Springer-Verlag
Year
2003
Tongue
English
Weight
587 KB
Volume
28
Category
Article
ISSN
0378-7966

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Validation of a simple HPLC method for D
Validation of a simple HPLC method for DRF-4848, a novel COX-2 inhibitor suitable for pharmacokinetic application in rats
โœ Raja Reddy Kallem; Ravi Kumar Trivedi; Ramesh Mullangi; Nuggehally R. Srinivas ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 141 KB ๐Ÿ‘ 2 views

For pharmacokinetic and toxicokinetic purpose a simple HPLC-UV method has been developed and validated for the estimation of DRF-4848, a novel COX-2 inhibitor in rat plasma. A liquid-liquid extraction was used to extract DRF-4848 and internal standard (IS, DRF-4367) from rat plasma. The analysis was