Oral and Infusion Levodopa-Based Strategies for Managing Motor Complications in Patients with Parkinson’s Disease
✍ Scribed by Antonini, Angelo; Chaudhuri, K. Ray; Martinez-Martin, Pablo; Odin, Per
- Book ID
- 120320780
- Publisher
- Adis International Limited (now part of Wolters Kluwer Health)
- Year
- 2010
- Tongue
- English
- Weight
- 166 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1172-7047
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## Abstract The cause of motor fluctuations occurring during constant‐rate levodopa infusions is unknown. We examined whether known pharmacokinetic factors could explain the fluctuations and looked for clues to pharmacodynamic causes. Eleven subjects with stage III–V Parkinson's disease (PD) and a
## Abstract We report our long‐term experience using enteral levodopa infusions in 22 patients with Parkinson's disease and severe motor fluctuations. Amelioration of intractable dyskinesias was the most important factor that determined whether patients chose to continue using the infusion pump sys