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Oral Administration of Insulin to Neonates Suppresses Spontaneous and Cyclophosphamide Induced Diabetes in the NOD Mouse

✍ Scribed by Ruth Maron; Mireia Guerau-De-Arellano; Xingmin Zhang; Howard L. Weiner

Book ID: 115621810
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 131 KB
Volume: 16
Category: Article
ISSN: 0896-8411
DOI: 10.1006/jaut.2000.0471

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The development of diabetes in non-obese diabetic (NOD) mice, which normally takes between 3 and 7 months, can be accelerated by cyclophosphamide (CY) injections, with rapid progression to diabetes within only 2±3 weeks. This insulin-dependent diabetes mellitus (IDDM) can be prevented or delayed in