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IL-18 binding protein fusion construct delays the development of diabetes in adoptive transfer and cyclophosphamide-induced diabetes in NOD mouse

✍ Scribed by Paola Zaccone; Jenny Phillips; Ignacio Conget; Anne Cooke; Ferdinando Nicoletti


Book ID
116366281
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
231 KB
Volume
115
Category
Article
ISSN
1090-2341

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The development of diabetes in non-obese diabetic (NOD) mice, which normally takes between 3 and 7 months, can be accelerated by cyclophosphamide (CY) injections, with rapid progression to diabetes within only 2Β±3 weeks. This insulin-dependent diabetes mellitus (IDDM) can be prevented or delayed in