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Optimized synthesis of [3-15N]-labeled uridine phosphoramidites

✍ Scribed by Bharat Baral; Pawan Kumar; Brooke A. Anderson; Michael E. Østergaard; Pawan K. Sharma; Patrick J. Hrdlicka

Book ID
104096854
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
227 KB
Volume
50
Category
Article
ISSN
0040-4039

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✦ Synopsis

A short and high-yielding synthetic route to [3-15 N]-labeled uridine phosphoramidite 1 (26% overall yield from uridine) has been developed. This will enable automated synthesis of isotopically labeled RNA strands and facilitate their use in structural studies.

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