✦ LIBER ✦

Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED

✍ Scribed by Craig D. Boyle; Ruo Xu; Theodros Asberom; Samuel Chackalamannil; John W. Clader; William J. Greenlee; Henry Guzik; Yuequing Hu; Zhiyong Hu; Claire M. Lankin; Dmitri A. Pissarnitski; Andrew W. Stamford; Yuguang Wang; Jeffrey Skell; Stanley Kurowski; Subbarao Vemulapalli; Jairam Palamanda; Madhu Chintala; Ping Wu; Joyce Myers; Peng Wang

Book ID: 108073599
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 141 KB
Volume: 15
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2005.02.083

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Optimization of Purine Based PDE1/PDE5 I

Optimization of Purine Based PDE1/PDE5 Inhibitors to a Potent and Selective PDE5 Inhibitor for the Treatment of Male ED.

✍ Craig D. Boyle; et al. et al. 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 19 KB 👁 1 views

## Abstract For Abstract see ChemInform Abstract in Full Text.

Phosphodiesterase 5 (PDE5) Inhibitors fo

Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Male Erectile Disorder: Attaining Selectivity versus PDE6

✍ Dmitri Pissarnitski 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 8 KB

Phosphodiesterase 5 (PDE 5) inhibitors f

Phosphodiesterase 5 (PDE 5) inhibitors for the treatment of male erectile disorder: Attaining selectivity versus PDE6

✍ Dmitri Pissarnitski 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 419 KB

## Abstract The role of phosphodiesterase type 5 (PDE5) in the mechanism of male erection has been well understood, and several drugs inhibiting this enzyme are being used for the treatment of erectile dysfunction (ED). Discovery of inhibitors with improved selectivity versus other PDE isozymes cou

Identification of chalcones as potent an

Identification of chalcones as potent and selective PDE5A1 inhibitors

✍ Ky-Youb Nam; Nam Song Choi; Cheol Kyu Han; Soon Kil Ahn 📂 Article 📅 2012 🏛 Elsevier Science 🌐 English ⚖ 739 KB

Novel PDE5 inhibitors for the treatment

Novel PDE5 inhibitors for the treatment of male erectile dysfunction

✍ JS Kalsi; G Bahadur; A Muneer; O Ozturk; N Christopher; DJ Ralph; S Minhas 📂 Article 📅 2003 🏛 Reproductive Healthcare Ltd 🌐 English ⚖ 193 KB

Pyrimidinylpyrroloquinolones as Highly P

Pyrimidinylpyrroloquinolones as Highly Potent and Selective PDE5 Inhibitors for Treatment of Erectile Dysfunction

✍ Sui, Zhihua; Guan, Jihua; Macielag, Mark J.; Jiang, Weiqin; Zhang, Suying; Qiu, 📂 Article 📅 2002 🏛 American Chemical Society 🌐 English ⚖ 84 KB