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Optimization of Purine Based PDE1/PDE5 Inhibitors to a Potent and Selective PDE5 Inhibitor for the Treatment of Male ED.

โœ Scribed by Craig D. Boyle; et al. et al.


Publisher
John Wiley and Sons
Year
2005
Weight
19 KB
Volume
36
Category
Article
ISSN
0931-7597

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โœฆ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


๐Ÿ“œ SIMILAR VOLUMES


Phosphodiesterase 5 (PDE 5) inhibitors f
โœ Dmitri Pissarnitski ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 419 KB

## Abstract The role of phosphodiesterase type 5 (PDE5) in the mechanism of male erection has been well understood, and several drugs inhibiting this enzyme are being used for the treatment of erectile dysfunction (ED). Discovery of inhibitors with improved selectivity versus other PDE isozymes cou