Spiroquinazolinones as Novel, Potent, and Selective PDE7 Inhibitors. Part 2. Optimization of 5,8-Disubstituted Derivatives.
β Scribed by Patrick Bernardelli; et al. et al.
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 19 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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Design and Synthesis of Novel 2,7-Dialkyl Substituted 5(S)-Amino-4(S)-hydroxy-8-phenyl-octanecarboxamides as in vitro Potent Peptidomimetic Inhibitors of Human Renin. -Novel renin inhibitors (I), which are created on a topographical design approach, are prepared by literature methods. (I) have IC 50